CRIMSON is based on state of the art scientific advancements on parallel computing, computational mechanics, cardiovascular physiology, and medical image processing. The following is a list of the main publications related to methods and techniques available in CRIMSON.

Main CRIMSON paper

Please cite this paper if you use CRIMSON in your work.

CRIMSON: An open-source Software Framework for Cardiovascular Integrated Modelling and Simulation (2021). C.J. Arthurs, R. Khlebnikov, A. Melville, A. Gomez, D. Dillon-Murphy, F. Cuomo, M. Silva Vieira, J. Schollenberger, S.R. Lynch, C. Tossas-Betancourt, K. Iyer, S. Hopper, E. Livingston, P. Youssefi, A. Noorani, S. Ben Ahmed, F.J.H. Nauta, T.M.J. van Bakel, Y. Ahmed, P.A.J. van Bakel, J. Mynard, P. Di Achille, H. Gharahi, K.D. Lau, V. Filonova, M. Aguirre, N. Nama, N. Xiao, S. Baek, K. Garikipati, O. Sahni, D. Nordsletten, C.A. Figueroa. PLOS: Computational Biology. DOI: 10.1371/journal.pcbi.1008881

Clinical Applications (first author is an M.D.)

  • Patient-specific computational modelling of different cannulation strategies for extracorporeal membrane oxygenation (2022). Y. Ahmed, S.R. Lynch, J.W. Haft, F.L. Moll, J.A. van Herwaarden, S.N. Burris, H.J. Patel, C. Alberto Figueroa. ASAIO. DOI: 10.1097/MAT.0000000000001819
  • Interventional planning for endovascular revision of a Lateral Tunnel Fontan: a patient-specific computational analysis (2021). Y. Ahmed, C. Tossas-Betancourt, P. van Bakel, J. Primeaux, W.J. Weadock, J.C. Lu, J.D. Zampi, A. Salavitabar, C. Alberto Figueroa. Frontiers in Physiology, Computational Physiology and Medicine. DOI: 10.3389/fphys.2021.718254
  • Mapping pre-dissection aortic wall abnormalities: a multiparametric assessment (2020). I. Houben, N. Nama, F.L. Moll, J.A. Herwaarden, D. Nordsletten, D.M. Williams, H.J. Patel, C.A. Figueroa, N. Burris. European Journal of Cardiothoracic Surgery. DOI: 10.1093/ejcts/ezz381
  • Ascending Aortic Rupture after Zone 2 Endovascular Repair: A Multi-Parametric Computational Study (2019). T.M.J. van Bakel, N. Burris, H.J. Patel, C.A. Figueroa. European Journal of Cardiothoracic Surgery. DOI: 10.1093/ejcts/ezy458
  • Cardiac Remodeling following Thoracic Endovascular Aortic Repair for Descending Aortic Aneurysms (2018). T.M.J. van Bakel, C.J. Arthurs, F.J.H. Nauta, K.A. Eagle, J.A. Herwaarden, F.L. Moll, S. Trimarchi, H.J. Patel, C.A. Figueroa. European Journal of Cardiothoracic Surgery. DOI: 10.1093/ejcts/ezy399
  • Patient-specific modeling of right coronary circulation vulnerability post-liver transplant in Alagille's syndrome (2018). M.S. Vieira, C.J. Arthurs, T. Hussain, R. Razavi, C.A. Figueroa. PLOS ONE. DOI: 10.1371/journal.pone.0205829
  • Hemodynamic Performance of Different Endograft Designs for Zone 0 Aortic Arch Repair: A Computational Study (2018). T.M.J. van Bakel, C.J. Arthurs, J.A. Herwaarden, F.L. Moll, K.A. Eagle, H.J. Patel, S. Trimarchi, C.A. Figueroa. European Journal of Cardio-Thoracic Surgery. DOI: 10.1093/ejcts/ezy068
  • Patient-Specific Modeling of Hemodynamics: Optimizing a Fontan Circulation Correction (2018). T.M.J. van Bakel, K.D. Lau, J. Hirsch-Romano, S. Trimarchi, A.L. Dorfman, C.A. Figueroa. Journal of Cardiovascular Translational Research. DOI: 10.1007/s12265-017-9781-x
  • Impact of Patient-specific Inflow Velocity Profiles on Haemodynamics of the Thoracic Aorta (2017). P. Youssefi, A. Gomez, C.J. Arthurs, R. Sharma, M. Jahangiri, C.A. Figueroa. Journal of Biomechanical Engineering. DOI: 10.1115/1.4037857
  • Patient- pecific Computational Fluid Dynamics - Assessment of Aortic Hem dynamics in a Spectrum of Ao ic Valve Pathologies (2017). P. Youssefi, A. Go ez, T. He, L. Anderson, N. Bunce, R. Sharma, C.A. Figueroa, M. Jahangiri. Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j. tcvs.20 6.09.040
  • Computational Fluid Dynamics and Aortic Thrombus Formation Following Thoracic En ovascular Aort c Repair (2017). F.J.H. Nau a, K.D. Lau, C.J. Arthurs, K.A. Eagle, D.M. Williams, S. Trimarchi, H.J. Patel, C.A. Figueroa. Annals of Thoracic Surgery. DOI: 10.1016/j.athoracsur.2016. 9.067
  • Functional Assessment f Thoracic Aortic Aneurysms - The Future of Risk Prediction? (2017). P. Youssefi, R. Sharma, C.A. Figueroa, M. Jahangiri. British Medical Bullet . DOI: 10.1093/bmb/ld 049
  • Computationa Study of Anat ical Risk Factors in Idealized Models of Type B Aortic Dissection (2016). S. Ben Ahmed, D. Dillon-Murphy, C.A. Figueroa. European Journal of Vascular and Endovascular Surgery. DOI: 10.1016/j.ejvs.2016.07.025

Stabilized Finite Element Formulation

Fluid-structure Interaction

  • A coupled momentum method for modeling blood flow in t ree-dimensional deformable arteries (2006). C.A. Figue oa, I.E. Vignon-Clementel, K.E. Jansen, T.J.R. Hughes, C.A. Taylor. Computer Methods in Applied Mecha ics and Engineering. DOI: 10.1016/j.cma.2005.11.011
  • External Tissue Support and Fluid-Structure Simulation in Blood Flows (2012). P. Moireau N. iao, M. Astorino, C.A. Figueroa, D. Chapelle, C.A. Taylor, J.F. Gerbeau. Biomechanics and Modeling in Mechanobiolog . DOI: 0.1007/s10237-011-0289-z
  • A Nonlinear Rotation-fre Shell Formulation with Pr -stressing for Vascular Biomechanics (2020). N. Nama, M. Aguirre, J.D. Humphrey, C.A. Figueroa. Nature Scientific Reports. DOI: 10.1038/s41598-020-74277-5

Boundary Conditions

  • Outflow boundary conditions for three-dimensional finite elem nt modeling of blood flow and pressure in arteries (20 6). I.E. Vignon-Clementel, C.A. Figueroa, K.E. Jansen, C.A. Taylor. Computer Methods in Applied Mechanics and Engineering. DOI: 10.1016/j.cma.2005.04.014
  • On Coupling a Lumped Parameter Heart Model and a Three-Dimensional Finite Element Aorta Model (2009). H.J. Kim, I.E Vig on-Clementel, C.A. Figueroa, J.F. LaDisa, K.E. Jansen, J.A. Feinstein, C.A. Taylor. Annals of Biomedical E gineering. DOI: 10.1007/s10439-009-9760-8
  • Patient-Specific Modeling of Blood Flow and Pressur in Human Coronary Arteries (2010 H.J Kim, I.E. Vignon-Clementel, J.S. Coogan, C.A. Figueroa, K.E. Jansen, C.A. Taylor. Annals of Biomedical Engineering. DOI: 10.1007/s10439-010-0083-6
  • Optimal B-Spline Mapping of Flow Imaging Data for Imposing Patient-Specific Velocity Profiles in omputational Haemodynamics (2018). A. Gomez, M. Marčan, C.J. Arthurs, R. Wright, P. Youssefi, M. Jahangiri, C.A. Figueroa. IEEE Transactions on Biomedical Engineering. DOI: 10.1109/TBME.2018.2880606

Parameter Estimation

Transitional CV Physiology

  • Simulation of short-term pressu e regulation during the tilt test in a coupl d 3D–0D closed-loop model of t e circulation (2015). K.D. Lau, C.A. Figueroa. Biomechanics and Modeling in Mechanobiology. DOI: 10.1007/s10237-014-0645-x
  • A Mathematical Model of Coronary Blood Flow Control: Simulation of Patient-Specific Three-Dimensional Haemodynamics during Exercise (2016). C.J. Arthu s, K.D. Lau, K.N. Asrress, S.R. Redwood, C.A. Figueroa. American Journal of Physiology - Heart and Circulatory Physiology. DOI: 10.1152/ajpheart.00517.2015